Andy Murray’s winning run came to an end with a straight-sets defeat by world number one Novak Djokovic in the quarter-finals of the Paris Masters.

The Briton, seeking his 12th win in a row, lost 7-5 6-2 against the defending champion in one hour and 41 minutes.

Murray, who has lost all four matches against the Serb this year, will now take a week off before the end-of-season World Tour Finals in London.

Djokovic will face Japan’s Kei Nishikori in the last four in Paris.

Murray, 27, has played 23 matches over the past six weeks, winning three titles, and could not prevent the Serb from winning the final five games of the match as fatigue took its toll.

But the Scot had already achieved a major goal by qualifying for the Tour finals with his win over Grigor Dimitrov on Thursday.

“The first set was tight, the second set I got up a break and lost my way a little bit,” he said of his defeat to Djokovic.

“I saw some stats after we finished and as soon as the rallies got over five shots I was winning more, but the rallies that finished before five shots, I think he won 25 more points.

“That would suggest that he was serving better and I didn’t return as well as him.

“It has been a positive run over the last few weeks and now I’ll get a bit of rest and ready for London.”

The result was a boost for Djokovic’s chances of ending the year at the top of the world rankings, especially as his nearest rival Roger Federer lost his quarter-final.

Milos Raonic beat world number two Federer 7-6 (7-4) 7-5 to gain his first win in seven meetings with the Swiss and secure his place at November’s World Tour Finals in London.

Raonic’s place, and the rest of the line-up at the season finale, was confirmed as Nishikori beat Spain’s David Ferrer 3-6 7-6 (7-5) 6-4.

Nishikori, 24, becomes the first Asian-born singles player to qualify for the event.

Earlier in the day, Czech fifth seed Tomas Berdych secured his place with a 6-7 (7-4) 6-4 6-4 over South African Kevin Anderson.

ATP World Tour Finals line-up

Qualifiers: Novak Djokovic, Roger Federer, Stan Wawrinka, Marin Cilic, Andy Murray, Tomas Berdych, Milos Raonic, Kei Nishikori
Absent: World number three Rafael Nadal is due to have his appendix removed
* The draw for the group stages will be made at 15:00 GMT on Monday and will be covered live on BBC Radio 5 live

Federer, 33, said that, although his hopes of regaining top spot in the rankings were dented, his defeat to Raonic would at least afford him more time to prepare for the World Tour Finals.

“I always thought it was going to get solved in London,” he said. “Whether I am number one at the end of this year, or one or two weeks later next year, it doesn’t really matter.

“Now I will have a good preparation for London. It’s not that I didn’t want to win here, but I knew it was going to be tough from the start.”